Remarks: “The evidence shows that SARS-CoV-2 should be a laboratory product created by using bat coronaviruses ZC45 and/or ZXC21 as a template and/or backbone. Building upon the evidence, we further postulate a synthetic route for SARS-CoV-2, demonstrating that the laboratory-creation of this coronavirus is convenient and can be accomplished in approximately six months. FULL STORY HERE: https://www.4cmitv.com/2020/09/16/2020-sep-14-dr-li-meng-yan-chinese-virologist-joins-twitter-publishes-smoking-gun-evidence-covid-19-created-in-lab/
Dr. Li-Meng Yan is a scientist who was working at the Hong Kong School of Public Health when she turned whistleblower on the Chinese Government, after she alleged they knew about the spread of the coronavirus before publicly acknowledging the outbreak.
As a result, Dr Yan claims she had to flee to the US for her own safety and is now determined to spread her findings to the world.
She joined the Loose Women from a secret location to tell us why she felt compelled to speak out, even if it meant putting her life on the line.
The Chinese National Health Commission, World Health Organisation and University Of Hong Kong dispute her claims.
Zerohedge Headline: ‘Rogue’ Chinese Virologist Joins Twitter, Publishes “Smoking Gun” Evidence COVID-19 Created In Lab
On Saturday we reported that Dr. Li-Meng Yan – a Chinese virologist (MD, PhD) who fled the country, leaving her job at a prestigious Hong Kong university – appeared last week on British television where she claimed SARS-CoV-2, the virus which causes COVID-19, was created by Chinese scientists in a lab.
On Sunday, Li-Meng joined Twitter – and on Monday, just hours ago, she tweeted a link to a paper she co-authored with three other Chinese scientists titled:
Unusual Features of the SARS-CoV-2 Genome Suggesting Sophisticated Laboratory Modification Rather Than Natural Evolution and Delineation of Its Probable Synthetic Route (PDF View Here)
She also posted a link to her credentials on ResearchGate, revealing her (prior?) affiliation with The University of Hong Kong and 13 publications which have been cited 557 times.
Cutting to the chase:
Here is the extended punchline:
The receptor-binding motif of SARS-CoV-2 Spike cannot be born from nature and should have been created through genetic engineering.
The Spike proteins decorate the exterior of the coronavirus particles.
They play an important role in infection as they mediate the interaction with host cell receptors and thereby help determine the host range and tissue tropism of the virus.
The Spike protein is split into two halves (Figure 3).
The front or N-terminal half is named S1, which is fully responsible for binding the host receptor.
In both SARS-CoV and SARS-CoV-2 infections, the host cell receptor is hACE2.
Within S1, a segment of around 70 amino acids makes direct contacts with hACE2 and is correspondingly named the receptor-binding motif (RBM) (Figure 3C).
In SARS-CoV and SARS-CoV-2, the RBM fully determines the interaction with hACE2.
The C-terminal half of the Spike protein is named S2.
The main function of S2 includes maintaining trimer formation and, upon successive protease cleavages at the S1/S2 junction and a downstream S2’ position, mediating membrane fusion to enable cellular entry of the virus.
Similar to what is observed for other viral proteins, S2 of SARS-CoV-2 shares a high sequence identity (95%) with S2 of ZC45/ZXC21. In stark contrast, between SARS-CoV-2 and ZC45/ZXC21, the S1 protein, which dictates which host (human or bat) the virus can infect, is much less conserved with the amino acid sequence identity being only 69%.
Figure 4 shows the sequence alignment of the Spike proteins from six β coronaviruses. Two are viruses isolated from the current pandemic (Wuhan-Hu-1, 2019-nCoV_USA-AZ1); two are the suspected template viruses (Bat_CoV_ZC45, Bat_CoV_ZXC21); two are SARS coronaviruses (SARS_GZ02, SARS).
The RBM is highlighted in between two orange lines. Clearly, despite the high sequence identity for the overall genomes, the RBM of SARS-CoV-2 differs significantly from those of ZC45 and ZXC21.
Intriguingly, the RBM of SARS-CoV-2 resembles, on a great deal, the RBM of SARS Spike. Although this is not an exact “copy and paste”, careful examination of the Spike-hACE2 structures37,38 reveals that all residues essential for either hACE2 binding or protein folding (orange sticks in Figure 3C and what is highlighted by red short lines in Figure 4) are “kept”.
Most of these essential residues are precisely preserved, including those involved in disulfide bond formation (C467, C474) and electrostatic interactions (R444, E452, R453, D454), which are pivotal for the structural integrity of the RBM (Figure 3C and 4).
The few changes within the group of essential residues are almost exclusively hydrophobic “substitutions” (I428àL, L443àF, F460àY, L472àF, Y484àQ), which should not affect either protein folding or the hACE2-interaction.
At the same time, majority of the amino acid residues that are non-essential have “mutated” (Figure 4, RBM residues not labeled with short red lines).
Judging from this sequence analysis alone, we were convinced early on that not only would the SARS-CoV-2 Spike protein bind hACE2 but also the binding would resemble, precisely, that between the original SARS Spike protein and hACE223.
Recent structural work has confirmed our prediction.
As elaborated below, the way that SARS-CoV-2 RBM resembles SARS-CoV RBM and the overall sequence conservation pattern between SARS-CoV-2 and ZC45/ZXC21 are highly unusual. Collectively, this suggests that portions of the SARS-CoV-2 genome have not been derived from natural quasi-species viral particle evolution.
The paper then makes two critical observations for those who claim that SARS-CoV-2 has a natural origin: its RBM could have only been acquired in one of the two possible routes: 1) an ancient recombination event followed by convergent evolution or 2) a natural recombination event that occurred fairly recently.
SHE FIRST DISMISSES OPTION 1:
SHE THEN DISMISSES OPTION 2:
WHICH LEAVES JUST ONE OPTION:
IT GETS BETTER, BECAUSE THE CHINESE SCIENTISTS THEN PRESCIENTLY TRIED TO COVER THEIR TRACKS:
Dr Li-Meng Yan; ALSO DISCUSSES THE INFAMOUS FURIN-CLEAVAGE SITE:
AND ANOTHER CRITICAL ALLEGATION:
Once again, the Wuhan Researchers were doing everything in their power to weaponize and boost the “enhancement of the infectivity and pathogenicity of the laboratory-made coronavirus”:
SUMMARIZING THE ABOVE:
Those curious how the virus could have been created synthetically in Wuhan, here is a diagram proposed by Dr. Yan explaining all the required steps:
HER FULL PAPER IS BELOW: here
Unusual Features of the SARS-CoV-2 Genome Suggesting Sophisticated Laboratory Modification Rather Than Natural Evolution and Delineation of Its Probable Synthetic Route
HTML Source: 4028830#.X2Db3WgzaUm
Authors: Yan, Li-Meng; Kang, Shu; Guan, Jie; Hu, Shanchang
Publication date: September 14, 2020
The COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 has led to over 910,000 deaths worldwide and unprecedented decimation of the global economy.
Despite its tremendous impact, the origin of SARS-CoV-2 has remained mysterious and controversial.
The natural origin theory, although widely accepted, lacks substantial support.
The alternative theory that the virus may have come from a research laboratory is, however, strictly censored on peer-reviewed scientific journals.
Nonetheless, SARS-CoV-2 shows biological characteristics that are inconsistent with a naturally occurring, zoonotic virus.
In this report, we describe the genomic, structural, medical, and literature evidence, which, when considered together, strongly contradicts the natural origin theory.
The evidence shows that SARS-CoV-2 should be a laboratory product created by using bat coronaviruses ZC45 and/or ZXC21 as a template and/or backbone.
Building upon the evidence, we further postulate a synthetic route for SARS-CoV-2, demonstrating that the laboratory-creation of this coronavirus is convenient and can be accomplished in approximately six months.
Our work emphasizes the need for an independent investigation into the relevant research laboratories.
It also argues for a critical look into certain recently published data, which, albeit problematic, was used to support and claim a natural origin of SARS-CoV-2.
From a public health perspective, these actions are necessary as knowledge of the origin of SARS-CoV-2 and of how the virus entered the human population are of pivotal importance in the fundamental control of the COVID-19 pandemic as well as in preventing similar, future pandemics.
And for those who missed it, here’s Li-Meng’s interview on UK television1)clip https://youtu.be/7Lq3_rsBJ9w: View Above
As a reminder, Zero Hedge was banned from Twitter on Jan 31 for making just this allegation, following a hit-piece written by an alleged pedophile (who was later fired for plagiarism) and countless so-called “scientists” screaming that our take was fake news and nothing but propaganda. Five months later Twitter admitted it had made a mistake, stating “we made an error in our enforcement action in this case.”
ORIGINAL SOURCE: Date-stamped: 2020 SEP 15 | Time-stamped: 04:35 | Author: Tyler Durden | Article Title: 'Rogue' Chinese Virologist Joins Twitter, Publishes "Smoking Gun" Evidence COVID-19 Created In Lab | Article Link: zerohedge.com
Hashtags: #4cminewswire, #LiMengYan, #SARSCoV2, #LaboratoryModification, #Wuhan, #COVID19, #4cminews, #4CMiTV, #4CM2020SEP14
Tags: 4cminewswire, Li-Meng Yan, SARS-CoV-2, Laboratory Modification, Wuhan, COVID-19, 4cminews, 4CMiTV, #4CM2020SEP14
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Reporter Political Pundit Commentary: Yes
Edited by 4cm: Yes
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Original-Source: Loose Women
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