2020 JUL 20 There is Information On Face Masks, Desperate Politicians Prefer Not To Tell

BACKGROUND: Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31142-9/fulltext

Derek K Chu, MD | Prof Elie A Akl, MD | Stephanie Duda, MSc | Karla Solo, MSc | Sally Yaacoub, MPH | Prof Holger J Schünemann, MD

Open Access Published: June 01, 2020 DOI: https://doi.org/10.1016/S0140-6736(20)31142-9

ARTICLES| VOLUME 395, ISSUE 10242, P1973-1987, JUNE 27, 2020

SUMMARY: 

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Summary

BACKGROUND

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19 and is spread person-to-person through close contact. We aimed to investigate the effects of physical distance, face masks, and eye protection on virus transmission in health-care and non-health-care (eg, community) settings.

METHODS

We did a systematic review and meta-analysis to investigate the optimum distance for avoiding person-to-person virus transmission and to assess the use of face masks and eye protection to prevent transmission of viruses.

We obtained data for SARS-CoV-2 and the betacoronaviruses that cause severe acute respiratory syndrome, and Middle East respiratory syndrome from 21 standard WHO-specific and COVID-19-specific sources.

We searched these data sources from database inception to May 3, 2020, with no restriction by language, for comparative studies and for contextual factors of acceptability, feasibility, resource use, and equity.

We screened records, extracted data, and assessed risk of bias in duplicate.

We did frequentist and Bayesian meta-analyses and random-effects meta-regressions. We rated the certainty of evidence according to Cochrane methods and the GRADE approach. This study is registered with PROSPERO, CRD42020177047.

FINDINGS

Our search identified 172 observational studies across 16 countries and six continents, with no randomised controlled trials and 44 relevant comparative studies in health-care and non-health-care settings (n=25 697 patients).

Transmission of viruses was lower with physical distancing of 1 m or more, compared with a distance of less than 1 m (n=10 736, pooled adjusted odds ratio [aOR] 0·18, 95% CI 0·09 to 0·38; risk difference [RD] −10·2%, 95% CI −11·5 to −7·5; moderate certainty); protection was increased as distance was lengthened (change in relative risk [RR] 2·02 per m; p_interaction=0·041; moderate certainty).

Face mask use could result in a large reduction in risk of infection (n=2647; aOR 0·15, 95% CI 0·07 to 0·34, RD −14·3%, −15·9 to −10·7; low certainty), with stronger associations with N95 or similar respirators compared with disposable surgical masks or similar (eg, reusable 12–16-layer cotton masks; p_interaction=0·090; posterior probability >95%, low certainty).

Eye protection also was associated with less infection (n=3713; aOR 0·22, 95% CI 0·12 to 0·39, RD −10·6%, 95% CI −12·5 to −7·7; low certainty). Unadjusted studies and subgroup and sensitivity analyses showed similar findings.

INTERPRETATION

The findings of this systematic review and meta-analysis support physical distancing of 1 m or more and provide quantitative estimates for models and contact tracing to inform policy.

Optimum use of face masks, respirators, and eye protection in public and health-care settings should be informed by these findings and contextual factors.

Robust randomised trials are needed to better inform the evidence for these interventions, but this systematic appraisal of currently best available evidence might inform interim guidance.

Introduction

As of May 28, 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than 5·85 million individuals worldwide and caused more than 359 000 deaths.^[1]01.01. Worldometer COVID-19 coronavirus pandemic. https://www.worldometers.info/coronavirus/ Date: 2020 Date accessed: May 28, 2020 • Google Scholar

Emergency lockdowns have been initiated in countries across the globe, and the effect on health, wellbeing, business, and other aspects of daily life are felt throughout societies and by individuals. With no effective pharmacological interventions or vaccine available in the imminent future, reducing the rate of infection (ie, flattening the curve) is a priority, and prevention of infection is the best approach to achieve this aim.

SARS-CoV-2 spreads person-to-person through close contact and causes COVID-19. It has not been solved if SARS-CoV-2 might spread through aerosols from respiratory droplets; so far, air sampling has found virus RNA in some studies^[2]02.01. Guo ZD Wang ZY Zhang SF et al. Aerosol and surface distribution of severe acute respiratory syndrome coronavirus 2 in hospital wards, Wuhan, China, 2020. Emerg Infect Dis. 2020; (published … Continue reading ^{| [3]}03.01. Chia PY Coleman KK Tan YK et al. Detection of air and surface contamination by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in hospital rooms of infected patients. medRxiv. … Continue reading ^{| [4]}04.01. Santarpia JL Rivera DN Herrera V et al. Transmission potential of SARS-CoV-2 in viral shedding observed at the University of Nebraska Medical Center. medRxiv. 2020; (published online March … Continue reading but not in others.^[5]05.01. Cheng V Wong S-C Chen J et al. Escalating infection control response to the rapidly evolving epidemiology of the coronavirus disease 2019 (COVID-19) due to SARS-CoV-2 in Hong Kong. Infect … Continue reading ^{| [6]}06.01. Wong SCY Kwong RT-S Wu TC et al. Risk of nosocomial transmission of coronavirus disease 2019: an experience in a general ward setting in Hong Kong. J Hosp Infect. 2020; 105: 119-127 • … Continue reading ^| [7]07.01. Faridi S Niazi S Sadeghi K et al. A field indoor air measurement of SARS-CoV-2 in the patient rooms of the largest hospital in Iran. Sci Total Environ. 2020; 725138401 • Crossref • PubMed … Continue reading ^| [8]08.01. Ong SWX Tan YK Chia PY et al. Air, surface environmental, and personal protective equipment contamination by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from a symptomatic … Continue reading

However, finding RNA virus is not necessarily indicative of replication-competent and infection-competent (viable) virus that could be transmissible. The distance from a patient that the virus is infective, and the optimum person-to-person physical distance, is uncertain. For the currently foreseeable future (ie, until a safe and effective vaccine or treatment becomes available), COVID-19 prevention will continue to rely on non-pharmaceutical interventions, including pandemic mitigation in community settings.^[9]09.01. Qualls N Levitt A Kanade N et al. Community mitigation guidelines to prevent pandemic influenza: United States, 2017. MMWR Recomm Rep. 2017; 66: 1-34 • Crossref • PubMed • Scopus (62) … Continue reading

Thus, quantitative assessment of physical distancing is relevant to inform safe interaction and care of patients with SARS-CoV-2 in both health-care and non-health-care settings. The definition of close contact or potentially exposed helps to risk stratify, contact trace, and develop guidance documents, but these definitions differ around the globe.

Research in context

Evidence before this study

We searched 21 databases and resources from inception to May 3, 2020, with no restriction by language, for studies of any design evaluating physical distancing, face masks, and eye protection to prevent transmission of the viruses that cause COVID-19 and related diseases (eg, severe acute respiratory syndrome [SARS] and Middle East respiratory syndrome [MERS]) between infected individuals and people close to them (eg, household members, caregivers, and health-care workers).

Previous related meta-analyses have focused on randomised trials and reported imprecise data for common respiratory viruses such as seasonal influenza, rather than the pandemic and epidemic beta-coronaviruses causative of COVID-19 (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]), SARS (SARS-CoV), or MERS (MERS-CoV).

Other meta-analyses have focused on interventions in the health-care setting and have not included non-health-care (eg, community) settings. Our search did not retrieve any systematic review of information on physical distancing, face masks, or eye protection to prevent transmission of SARS-CoV-2, SARS-CoV, and MERS-CoV.

Added value of this study

We did a systematic review of 172 observational studies in health-care and non-health-care settings across 16 countries and six continents; 44 comparative studies were included in a meta-analysis, including 25 697 patients with COVID-19, SARS, or MERS.

Our findings are, to the best of our knowledge, the first to rapidly synthesise all direct information on COVID-19 and, therefore, provide the best available evidence to inform optimum use of three common and simple interventions to help reduce the rate of infection and inform non-pharmaceutical interventions, including pandemic mitigation in non-health-care settings.

Physical distancing of 1 m or more was associated with a much lower risk of infection, as was use of face masks (including N95 respirators or similar and surgical or similar masks [eg, 12–16-layer cotton or gauze masks]) and eye protection (eg, goggles or face shields). Added benefits are likely with even larger physical distances (eg, 2 m or more based on modelling) and might be present with N95 or similar respirators versus medical masks or similar.

Across 24 studies in health-care and non-health-care settings of contextual factors to consider when formulating recommendations, most stakeholders found these personal protection strategies acceptable, feasible, and reassuring but noted harms and contextual challenges, including frequent discomfort and facial skin breakdown, high resource use linked with the potential to decrease equity, increased difficulty communicating clearly, and perceived reduced empathy of care providers by those they were caring for.

Implications of all the available evidence

In view of inconsistent guidelines by various organisations based on limited information, our findings provide some clarification and have implications for multiple stakeholders. The risk for infection is highly dependent on distance to the individual infected and the type of face mask and eye protection worn.

From a policy and public health perspective, current policies of at least 1 m physical distancing seem to be strongly associated with a large protective effect, and distances of 2 m could be more effective.

These data could also facilitate harmonisation of the definition of exposed (eg, within 2 m), which has implications for contact tracing. The quantitative estimates provided here should inform disease-modelling studies, which are important for planning pandemic response efforts.

Policy makers around the world should strive to promptly and adequately address equity implications for groups with currently limited access to face masks and eye protection. For health-care workers and administrators, our findings suggest that N95 respirators might be more strongly associated with protection from viral transmission than surgical masks.

Both N95 and surgical masks have a stronger association with protection compared with single-layer masks. Eye protection might also add substantial protection. For the general public, evidence shows that physical distancing of more than 1 m is highly effective and that face masks are associated with protection, even in non-health-care settings, with either disposable surgical masks or reusable 12–16-layer cotton ones, although much of this evidence was on mask use within households and among contacts of cases.

Eye protection is typically underconsidered and can be effective in community settings. However, no intervention, even when properly used, was associated with complete protection from infection. Other basic measures (eg, hand hygiene) are still needed in addition to physical distancing and use of face masks and eye protection.

To contain widespread infection and to reduce morbidity and mortality among health-care workers and others in contact with potentially infected people, jurisdictions have issued conflicting advice about physical or social distancing.

Use of face masks with or without eye protection to achieve additional protection is debated in the mainstream media and by public health authorities, in particular the use of face masks for the general population;^[10]10.01. Feng S Shen C Xia N Song W Fan M Cowling BJ Rational use of face masks in the COVID-19 pandemic. Lancet Respir Med. 2020; 8: 434-436 • Summary • Full Text • Full Text PDF • PubMed • … Continue reading moreover, optimum use of face masks in health-care settings, which have been used for decades for infection prevention, is facing challenges amid personal protective equipment (PPE) shortages.^[11]11.01. MacIntyre R Chughtai A Tham CD Seale H COVID-19: should cloth masks be used by healthcare workers as a last resort? … Continue reading

Any recommendations about social or physical distancing, and the use of face masks, should be based on the best available evidence. Evidence has been reviewed for other respiratory viral infections, mainly seasonal influenza,^[12]12.01. Loeb M Dafoe N Mahony J et al. Surgical mask vs N95 respirator for preventing influenza among health care workers: a randomized trial. JAMA. 2009; 302: 1865-1871 • Crossref • PubMed • … Continue reading ^{| [13]}13.01. Bartoszko JJ Farooqi MAM Alhazzani W Loeb M Medical masks vs N95 respirators for preventing COVID-19 in healthcare workers: a systematic review and meta-analysis of randomized trials. … Continue reading but no comprehensive review is available of information on SARS-CoV-2 or related betacoronaviruses that have caused epidemics, such as severe acute respiratory syndrome (SARS) or Middle East respiratory syndrome (MERS). We, therefore, systematically reviewed the effect of physical distance, face masks, and eye protection on transmission of SARS-CoV-2, SARS-CoV, and MERS-CoV.

Methods

 Search strategy and selection criteria

To inform WHO guidance documents, on March 25, 2020, we did a rapid systematic review.^[14]14.01. Schünemann HJ Moja L Reviews: rapid! Rapid! Rapid! . . . and systematic. Syst Rev. 2015; 4: 4 • Crossref • PubMed • Scopus (49) • Google Scholar

We created a large international collaborative and we used Cochrane methods^[15]15.01. Cochrane Training Cochrane handbook for systematic reviews of interventions, version 6. https://training.cochrane.org/handbook/current Date: 2019 Date accessed: May 12, 2020 • Google Scholar and the GRADE approach.^[16]16.01. Guyatt GH Oxman AD Vist GE et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008; 336: 924-926 • Crossref • PubMed • Google Scholar

We prospectively submitted the systematic review protocol for registration on PROSPERO (CRD42020177047; appendix pp 23–29). We have followed PRISMA^[17]17.01. Moher D Liberati A Tetzlaff J Altman DG Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol. 2009; 62: 1006-1012 • Summary • Full … Continue reading and MOOSE^[18]18.01. Stroup DF Berlin JA Morton SC et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. JAMA. 2000; 283: 2008-2012 • Crossref • PubMed • Scopus (11243) • … Continue reading reporting guidelines (appendix pp 30–33).

From database inception to May 3, 2020, we searched for studies of any design and in any setting that included patients with WHO-defined confirmed or probable COVID-19, SARS, or MERS, and people in close contact with them, comparing distances between people and COVID-19 infected patients of 1 m or larger with smaller distances, with or without a face mask on the patient, or with or without a face mask, eye protection, or both on the exposed individual.

The aim of our systematic review was for quantitative assessment to ascertain the physical distance associated with reduced risk of acquiring infection when caring for an individual infected with SARS-CoV-2, SARS-CoV, or MERS-CoV. Our definition of face masks included surgical masks and N95 respirators, among others; eye protection included visors, faceshields, and goggles, among others.

We searched (up to March 26, 2020) MEDLINE (using the Ovid platform), PubMed, Embase, CINAHL (using the Ovid platform), the Cochrane Library, COVID-19 Open Research Dataset Challenge, COVID-19 Research Database (WHO), Epistemonikos (for relevant systematic reviews addressing MERS and SARS, and its COVID-19 Living Overview of the Evidence platform), EPPI Centre living systematic map of the evidence, ClinicalTrials.gov, WHO International Clinical Trials Registry Platform, relevant documents on the websites of governmental and other relevant organisations, reference lists of included papers, and relevant systematic reviews.^[19]19.01. Jefferson T Del Mar CB Dooley L et al. Physical interventions to interrupt or reduce the spread of respiratory viruses. Cochrane Database Syst Rev. 2011; 7CD006207 • PubMed • Google Scholar ^{| [20]}20.01. Offeddu V Yung CF Low MSF Tam CC Effectiveness of masks and respirators against respiratory infections in healthcare workers: a systematic review and meta-analysis. Clin Infect Dis. 2017; 65: … Continue reading

We hand searched (up to May 3, 2020) preprint servers (bioRxiv, medRxiv, and Social Science Research Network First Look) and coronavirus resource centres of The Lancet, JAMA, and N Engl J Med (appendix pp 3–5). We did not limit our search by language. We initially could not obtain three full texts for evaluation, but we obtained them through interlibrary loan or contacting a study author. We did not restrict our search to any quantitative cutoff for distance.

Data collection

We screened titles and abstracts, reviewed full texts, extracted data, and assessed risk of bias by two authors and independently, using standardised prepiloted forms (Covidence; Veritas Health Innovation, Melbourne, VIC, Australia), and we cross-checked screening results using artificial intelligence (Evidence Prime, Hamilton, ON, Canada).

We resolved disagreements by consensus. We extracted data for study identifier, study design, setting, population characteristics, intervention and comparator characteristics, quantitative outcomes, source of funding and reported conflicts of interests, ethics approval, study limitations, and other important comments.

Outcomes

Outcomes of interest were risk of transmission (ie, WHO-defined confirmed or probable COVID-19, SARS, or MERS) to people in health-care or non-health-care settings by those infected; hospitalisation; intensive care unit admission; death; time to recovery; adverse effects of interventions; and contextual factors such as acceptability, feasibility, effect on equity, and resource considerations related to the interventions of interest.

However, data were only available to analyse intervention effects for transmission and contextual factors. Consistent with WHO, studies generally defined confirmed cases with laboratory confirmation (with or without symptoms) and probable cases with clinical evidence of the respective infection (ie, suspected to be infected) but for whom confirmatory testing either had not yet been done for any reason or was inconclusive.

DATA ANALYSIS

Our search did not identify any randomised trials of COVID-19, SARS, or MERS. We did a meta-analysis of associations by pooling risk ratios (RRs) or adjusted odds ratios (aORs) depending on availability of these data from observational studies, using DerSimonian and Laird random-effects models. We adjusted for variables including age, sex, and severity of source case; these variables were not the same across studies. Because between-study heterogeneity can be misleadingly large when quantified by I² during meta-analysis of observational studies,^[21]21.01. Guyatt GH Oxman AD Kunz R et al. GRADE guidelines, 7: rating the quality of evidence—inconsistency. J Clin Epidemiol. 2011; 64: 1294-1302 • Summary • Full Text • Full Text PDF • … Continue reading ^{| [22]}22.01. Iorio A Spencer FA Falavigna M et al. Use of GRADE for assessment of evidence about prognosis: rating confidence in estimates of event rates in broad categories of patients. BMJ. 2015; 350: … Continue reading we used GRADE guidance to assess between-study heterogeneity.^[23]21.02. Guyatt GH Oxman AD Kunz R et al. GRADE guidelines, 7: rating the quality of evidence—inconsistency. J Clin Epidemiol. 2011; 64: 1294-1302 • Summary • Full Text • Full Text PDF • … Continue reading

Throughout, we present RRs as unadjusted estimates and aORs as adjusted estimates.

We used the Newcastle-Ottawa scale to rate risk of bias for comparative non-randomised studies corresponding to every study’s design (cohort or case-control).^[24]23.01. Moskalewicz A Oremus M No clear choice between Newcastle-Ottawa Scale and Appraisal Tool for Cross-Sectional Studies to assess methodological quality in cross-sectional studies of … Continue reading ^{| [25]}24.01. Wells GA Shea B O’Connell D et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of non-randomised studies in meta-analyses. … Continue reading

We planned to use the Cochrane Risk of Bias tool 2.0 for randomised trials,^[26]25.01. Sterne JAC Savović J Page MJ et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019; 366l4898  • Crossref • PubMed • Scopus (282) • Google Scholar but our search did not identify any eligible randomised trials. We synthesised data in both narrative and tabular formats. We graded the certainty of evidence using the GRADE approach. We used the GRADEpro app to rate evidence and present it in GRADE evidence profiles and summary of findings tables^[27]26.01. Guyatt G Oxman AD Akl EA et al. GRADE guidelines, 1: introduction—GRADE evidence profiles and summary of findings tables. J Clin Epidemiol. 2011; 64: 383-394 • Summary • Full Text • … Continue reading ^{| [28]}27.01. Guyatt GH Thorlund K Oxman AD et al. GRADE guidelines, 13: preparing summary of findings tables and evidence profiles—continuous outcomes. J Clin Epidemiol. 2013; 66: 173-183 • Summary • … Continue reading using standardised terms.^[29]28.01. Santesso N Carrasco-Labra A Langendam M et al. Improving GRADE evidence tables part 3: detailed guidance for explanatory footnotes supports creating and understanding GRADE certainty in the … Continue reading ^{| [30]}29.01. Santesso N Glenton C Dahm P et al. GRADE guidelines, 26: informative statements to communicate the findings of systematic reviews of interventions. J Clin Epidemiol. 2020; 119: 126-135 • … Continue reading

We analysed data for subgroup effects by virus type, intervention (different distances or face mask types), and setting (health care vs non-health care). Among the studies assessing physical distancing measures to prevent viral transmission, the intervention varied (eg, direct physical contact [0 m], 1 m, or 2 m).

We, therefore, analysed the effect of distance on the size of the associations by random-effects univariate meta-regressions, using restricted maximum likelihood, and we present mean effects and 95% CIs. We calculated tests for interaction using a minimum of 10 000 Monte Carlo random permutations to avoid spurious findings.^[31]30.01. Higgins JP Thompson SG Controlling the risk of spurious findings from meta-regression. Stat Med. 2004; 23: 1663-1682 • Crossref • PubMed • Scopus (708) • Google Scholar

We formally assessed the credibility of potential effect-modifiers using GRADE guidance.^[32]21.03. Guyatt GH Oxman AD Kunz R et al. GRADE guidelines, 7: rating the quality of evidence—inconsistency. J Clin Epidemiol. 2011; 64: 1294-1302 • Summary • Full Text • Full Text PDF  … Continue reading

We did two sensitivity analyses to test the robustness of our findings. First, we used Bayesian meta-analyses to reinterpret the included studies considering priors derived from the effect point estimate and variance from a meta-analysis of ten randomised trials evaluating face mask use versus no face mask use to prevent influenza-like illness in health-care workers.^[33]31.01. Jefferson T Jones M Al Ansari LA et al. Physical interventions to interrupt or reduce the spread of respiratory viruses, part 1: face masks, eye protection and person distancing—systematic … Continue reading

Second, we used Bayesian meta-analyses to reinterpret the efficacy of N95 respirators versus medical masks on preventing influenza-like illness after seasonal viral (mostly influenza) infection.^[34]13.02. Bartoszko JJ Farooqi MAM Alhazzani W Loeb M Medical masks vs N95 respirators for preventing COVID-19 in healthcare workers: a systematic review and meta-analysis of randomized trials. … Continue reading 

For these sensitivity analyses, we used hybrid Metropolis-Hastings and Gibbs sampling, a 10 000 sample burn-in, 40 000 Markov chain Monte Carlo samples, and we tested non-informative and sceptical priors (eg, four time variance)^[35]32.01. Sutton AJ Abrams KR Bayesian methods in meta-analysis and evidence synthesis. Stat Methods Med Res. 2001; 10: 277-303  • Crossref • PubMed • Scopus (375) • Google Scholar ^{| [36]}33.01. Goligher EC Tomlinson G Hajage D et al. Extra-corporeal membrane oxygenation for severe acute respiratory distress syndrome and posterior probability of mortality benefit in a post hoc … Continue reading to inform mean estimates of effect, 95% credibility intervals (CrIs), and posterior distributions. We used non-informative hyper-priors to estimate statistical heterogeneity. Model convergence was confirmed in all cases with good mixing in visual inspection of trace plots, auto-correlation plots, histograms, and kernel density estimates in all scenarios. Parameters were blocked, leading to acceptance of approximately 50% and efficiency greater than 1% in all cases (typically about 40%). We did analyses using Stata version 14.3.

Role of the funding source

The funder contributed to defining the scope of the review but otherwise had no role in study design and data collection. Data were interpreted and the report drafted and submitted without funder input, but according to contractual agreement, the funder provided review at the time of final publication. The corresponding author had full access to all data in the study and had final responsibility for the decision to submit for publication.

Results

We identified 172 studies for our systematic review from 16 countries across six continents (figure 1; appendix pp 6–14, 41–47). Studies were all observational in nature; no randomised trials were identified of any interventions that directly addressed the included study populations.

Of the 172 studies, 66 focused on how far a virus can travel by comparing the association of different distances on virus transmission to people (appendix pp 42–44). Of these 66 studies, five were mechanistic, assessing viral RNA, virions, or both cultured from the environment of an infected patient (appendix p 45).

Figure 1 Study selection

Figure 1 Study selection 

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Risk factors for SARS infection among hospital healthcare workers in Beijing: a case control study. Trop Med Int Health. 2009; 14: 52-59  • Crossref  • … Continue reading ^{| [55]}52.01. Liu ZQ; Ye Y; Zhang H; Guohong X; Yang J; Wang JL. Analysis of the spatio-temporal characteristics and transmission path of COVID-19 cluster cases in Zhuhai. Trop Geogr. 2020; (published … Continue reading ^{| [56]}53.01. Loeb M; McGeer A; Henry B; et al. SARS among critical care nurses, Toronto. Emerg Infect Dis. 2004; 10: 251-255 • Crossref • PubMed • Scopus (165) • Google Scholar ^{| [57]}54.01. Ma HJ; Wang HW; Fang LQ. et al. A case-control study on the risk factors of severe acute respiratory syndromes among health care workers. Zhonghua Liu Xing Bing Xue Za Zhi. 2004; 25 (in … Continue reading ^{| [58]}55.01. Nishiura H; Kuratsuji T; Quy T. et al. Rapid awareness and transmission of severe acute respiratory syndrome in Hanoi French Hospital, Vietnam. Am J Trop Med Hyg. 2005; 73: 17-25  • … Continue reading ^{| [59]}56.01. Nishiyama A; Wakasugi N; Kirikae T. et al. Risk factors for SARS infection within hospitals in Hanoi, Vietnam. Jpn J Infect Dis. 2008; 61: 388-390  • PubMed • Google Scholar ^{| [60]}57.01. Olsen SJ; Chang HL; Cheung TY. et al. Transmission of the severe acute respiratory syndrome on aircraft. N Engl J Med. 2003; 349: 2416-2422 • Crossref • PubMed • Scopus (301) • Google … Continue reading ^{| [61]}58.01. Park BJ; Peck AJ; Kuehnert MJ. et al. Lack of SARS transmission among healthcare workers, United States. Emerg Infect Dis. 2004; 10: 244-248 • Crossref • PubMed • Google Scholar ^{| [62]}59.01. Park JY; Kim BJ; Chung KH; Hwang YI. Factors associated with transmission of Middle East respiratory syndrome among Korean healthcare workers: infection control via extended healthcare contact … Continue reading ^{| [63]}60.01. Peck AJ; Newbern EC; Feikin DR; et al. Lack of SARS transmission and U.S. SARS case-patient. Emerg Infect Dis. 2004; 10: 217-224 • Crossref • PubMed • Scopus (11) • Google Scholar ^{| [64]}61.01. Pei LY; Gao ZC; Yang Z. et al. Investigation of the influencing factors on severe acute respiratory syndrome among health care workers. Beijing Da Xue Xue Bao Yi Xue Ban. 2006; 38: 271-275 • … Continue reading ^{| [65]}62.01. Rea E; Laflèche J; Stalker S. et al. Duration and distance of exposure are important predictors of transmission among community contacts of Ontario SARS cases. Epidemiol Infect. 2007; 135: … Continue reading ^{| [66]}63.01. Reuss A; Litterst A; Drosten C. et al. Contact investigation for imported case of Middle East respiratory syndrome, Germany. Emerg Infect Dis. 2014; 20: 620-625 • Crossref • PubMed • … Continue reading ^{| [67]}64.01. Reynolds MG; Anh BH; Thu VH. et al. Factors associated with nosocomial SARS-CoV transmission among healthcare workers in Hanoi, Vietnam, 2003. BMC Public Health. 2006; 6: 207 • Crossref • … Continue reading ^{| [68]}65.01. Ryu B; Cho SI; Oh MD. et al. Seroprevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) in public health workers responding to a MERS outbreak in Seoul, Republic of Korea, in … Continue reading ^{| [69]}66.01. Scales DC; Green K; Chan AK. et al. Illness in intensive care staff after brief exposure to severe acute respiratory syndrome. Emerg Infect Dis. 2003; 9: 1205-1210 • Crossref • PubMed • … Continue reading ^{| [70]}67.01. Seto WH; Tsang D; Yung RWH. et al. Effectiveness of precautions against droplets and contact in prevention of nosocomial transmission of severe acute respiratory syndrome (SARS). Lancet. 2003; … Continue reading ^{| [71]}68.01. Teleman MD; Boudville IC; Heng BH; Zhu D; Leo YS. Factors associated with transmission of severe acute respiratory syndrome among health-care workers in Singapore. Epidemiol Infect. 2004; 132: … Continue reading ^{| [72]}69.01. Tuan PA; Horby P; Dinh PN. et al. SARS transmission in Vietnam outside of the health-care setting. Epidemiol Infect. 2007; 135: 392-401 • Crossref • PubMed • Scopus (4) • Google Scholar ^{| [73]}70.01. Wang Q; Huang X; Bai Y; et al. Epidemiological characteristics of COVID-19 in medical staff members of neurosurgery departments in Hubei province: a multicentre descriptive study. … Continue reading ^{| [74]}71.01. Wiboonchutikul S; Manosuthi W; Likanonsakul S; et al. Lack of transmission among healthcare workers in contact with a case of Middle East respiratory syndrome coronavirus infection in … Continue reading ^{| [75]}72.01. Wilder-Smith A; Teleman MD; Heng BH; Earnest A; Ling AE; Leo YS. Asymptomatic SARS coronavirus infection among healthcare workers, Singapore. Emerg Infect Dis. 2005; 11: 1142-1145  • … Continue reading ^{| [76]}73.01. Wong TW; Lee CK; Tam W; et al. Cluster of SARS among medical students exposed to single patient, Hong Kong. Emerg Infect Dis. 2004; 10: 269-276 • Crossref • PubMed • Scopus (145) … Continue reading ^{| [77]}74.01. Wu J; Xu F; Zhou W; et al. Risk factors for SARS among persons without known contact with SARS patients, Beijing, China. Emerg Infect Dis. 2004; 10: 210-216 • Crossref • PubMed • … Continue reading ^{| [78]}75.01. Yin WW; Gao LD; Lin WS; et al. Effectiveness of personal protective measures in prevention of nosocomial transmission of severe acute respiratory syndrome. Zhonghua Liu Xing Bing Xue Za … Continue reading ^{| [79]}76.01. Yu ITS; Wong TW; Chiu YL; Lee N; Li Y. Temporal-spatial analysis of severe acute respiratory syndrome among hospital inpatients. Clin Infect Dis. 2005; 40: 1237-1243 • Crossref • … Continue reading ^{| [80]}77.01. • Yu IT • Xie ZH • Tsoi KK; et al. Why did outbreaks of severe acute respiratory syndrome occur in some hospital wards but not in others?. Clin Infect Dis. 2007; 44: 1017-1025 • … Continue reading and fulfilled criteria for our meta-analysis (n=25 697; figure 1; table 1). We used these studies rather than case series and qualitative studies (appendix pp 41–47) to inform estimates of effect.

30 studies^[81]34.02. Alraddadi BM Al-Salmi HS Jacobs-Slifka K et al. Risk factors for Middle East respiratory syndrome coronavirus infection among healthcare personnel. Emerg Infect Dis. 2016; 22: 1915-1920 ^{| [82]}37.02. Burke RM; Balter S; Barnes E; et al. Enhanced contact investigations for nine early travel-related cases of SARS-CoV-2 in the United States. medRxiv. 2020; (published online May 3.) … Continue reading ^| [83]41.02. Wang X; Pan Z; Cheng Z; Association between 2019-nCoV transmission and N95 respirator use. J Hosp Infect. 2020; 105: 104-105 • Summary • Full Text • Full Text PDF • PubMed • Scopus … Continue reading ^| [84]42.02. Ha LD; Bloom SA; Hien NQ; et al. Lack of SARS transmission among public hospital workers, Vietnam. Emerg Infect Dis. 2004; 10: 265-268 • Summary • Full Text • Full Text PDF • Crossref … Continue reading ^| [85]43.02. Hall AJ; Tokars JI; Badreddine SA; et al. Health care worker contact with MERS patient, Saudi Arabia. Emerg Infect Dis. 2014; 20: 2148-2151 • Summary • Full Text • Full Text PDF • … Continue reading ^{| [86]}44.02. Heinzerling A; Stuckey MJ; Scheuer T. et al. Transmission of COVID-19 to health care personnel during exposures to a hospitalized patient: Solano County, California, February 2020. MMWR Morb … Continue reading  ^{| [87]}45.02. Ho KY; Singh KS; Habib AG. et al. Mild illness associated with severe acute respiratory syndrome coronavirus infection: lessons from a prospective seroepidemiologic study of health-care … Continue reading ^{| [88]}47.02. Ki HK; Han SK; Son JS; Park SO. Risk of transmission via medical employees and importance of routine infection-prevention policy in a nosocomial outbreak of Middle East respiratory syndrome … Continue reading ^{| [89]}48.02. Kim T; Jung J; Kim SM; et al. Transmission among healthcare worker contacts with a Middle East respiratory syndrome patient in a single Korean centre. Clin Microbiol Infect. 2016; 22: e11-e13 … Continue reading ^| [90]49.02. Kim CJ; Choi WS; Jung Y; et al. Surveillance of the Middle East respiratory syndrome (MERS) coronavirus (CoV) infection in healthcare workers after contact with confirmed MERS patients: … Continue reading ^| [91]52.01. Liu ZQ; Ye Y; Zhang H; Guohong X; Yang J; Wang JL. Analysis of the spatio-temporal characteristics and transmission path of COVID-19 cluster cases in Zhuhai. Trop Geogr. 2020; (published … Continue reading ^| [92]51.02. Liu W; Tang F; Fang LQ. et al. Risk factors for SARS infection among hospital healthcare workers in Beijing: a case control study. Trop Med Int Health. 2009; 14: 52-59  • Crossref  • … Continue reading ^{| [93]}53.02. Loeb M; McGeer A; Henry B; et al. SARS among critical care nurses, Toronto. Emerg Infect Dis. 2004; 10: 251-255 • Crossref • PubMed • Scopus (165) • Google Scholar ^| [94]54.02. Ma HJ; Wang HW; Fang LQ. et al. A case-control study on the risk factors of severe acute respiratory syndromes among health care workers. Zhonghua Liu Xing Bing Xue Za Zhi. 2004; 25 (in … Continue reading ^| [95]55.02. Nishiura H; Kuratsuji T; Quy T. et al. Rapid awareness and transmission of severe acute respiratory syndrome in Hanoi French Hospital, Vietnam. Am J Trop Med Hyg. 2005; 73: 17-25  • … Continue reading ^| [96]56.02. Nishiyama A; Wakasugi N; Kirikae T. et al. Risk factors for SARS infection within hospitals in Hanoi, Vietnam. Jpn J Infect Dis. 2008; 61: 388-390  • PubMed • Google Scholar ^{| [97]}58.02. Park BJ; Peck AJ; Kuehnert MJ. et al. Lack of SARS transmission among healthcare workers, United States. Emerg Infect Dis. 2004; 10: 244-248 • Crossref • PubMed • Google Scholar ^| [98]59.02. Park JY; Kim BJ; Chung KH; Hwang YI. Factors associated with transmission of Middle East respiratory syndrome among Korean healthcare workers: infection control via extended healthcare contact … Continue reading ^{| [99]}60.02. Peck AJ; Newbern EC; Feikin DR; et al. Lack of SARS transmission and U.S. SARS case-patient. Emerg Infect Dis. 2004; 10: 217-224 • Crossref  • PubMed • Scopus (11) • Google Scholar ^| [100]61.02. Pei LY; Gao ZC; Yang Z. et al. Investigation of the influencing factors on severe acute respiratory syndrome among health care workers. Beijing Da Xue Xue Bao Yi Xue Ban. 2006; 38: 271-275 • … Continue reading ^| [101]64.02. Reynolds MG; Anh BH; Thu VH. et al. Factors associated with nosocomial SARS-CoV transmission among healthcare workers in Hanoi, Vietnam, 2003. BMC Public Health. 2006; 6: 207 • Crossref • … Continue reading ^| [102]65.02. Ryu B; Cho SI; Oh MD. et al. Seroprevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) in public health workers responding to a MERS outbreak in Seoul, Republic of Korea, in … Continue reading ^| [103]66.02. Scales DC; Green K; Chan AK. et al. Illness in intensive care staff after brief exposure to severe acute respiratory syndrome. Emerg Infect Dis. 2003; 9: 1205-1210 • Crossref • PubMed • … Continue reading ^| [104]67.02. Seto WH; Tsang D; Yung RWH. et al. Effectiveness of precautions against droplets and contact in prevention of nosocomial transmission of severe acute respiratory syndrome (SARS). Lancet. 2003; … Continue reading ^| [105]68.02. Teleman MD; Boudville IC; Heng BH; Zhu D; Leo YS. Factors associated with transmission of severe acute respiratory syndrome among health-care workers in Singapore. Epidemiol Infect. 2004; 132: … Continue reading ^{| [106]}69.02. Tuan PA; Horby P; Dinh PN. et al. SARS transmission in Vietnam outside of the health-care setting. Epidemiol Infect. 2007; 135: 392-401 • Crossref • PubMed • Scopus (4) • Google Scholar ^| [107]70.02. Wang Q; Huang X; Bai Y; et al. Epidemiological characteristics of COVID-19 in medical staff members of neurosurgery departments in Hubei province: a multicentre descriptive study. medRxiv. … Continue reading ^| [108]72.02. Wilder-Smith A; Teleman MD; Heng BH; Earnest A; Ling AE; Leo YS. Asymptomatic SARS coronavirus infection among healthcare workers, Singapore. Emerg Infect Dis. 2005; 11: 1142-1145  • … Continue reading ^| [109]74.02. Wu J; Xu F; Zhou W; et al. Risk factors for SARS among persons without known contact with SARS patients, Beijing, China. Emerg Infect Dis. 2004; 10: 210-216 • Crossref • PubMed • Scopus … Continue reading ^| [110]75.02. Yin WW; Gao LD; Lin WS; et al. Effectiveness of personal protective measures in prevention of nosocomial transmission of severe acute respiratory syndrome. Zhonghua Liu Xing Bing Xue Za Zhi. … Continue reading focused on the association between use of various types of face masks and respirators by health-care workers, patients, or both with virus transmission. 13 studies^[111]34.03. Alraddadi BM Al-Salmi HS Jacobs-Slifka K et al. Risk factors for Middle East respiratory syndrome coronavirus infection among healthcare personnel. Emerg Infect Dis. 2016; 22: 1915-1920 ^{| [112]}37.03. Burke RM; Balter S; Barnes E; et al. Enhanced contact investigations for nine early travel-related cases of SARS-CoV-2 in the United States. medRxiv. 2020; (published online May 3.) … Continue reading ^| [113]38.02. Caputo KM; Byrick R; Chapman MG; Orser BJ; Orser BA. Intubation of SARS patients: infection and perspectives of healthcare workers. Can J Anaesth. 2006; 53: 122-129 • Crossref • PubMed • … Continue reading ^| [114]39.02. Chen WQ; Ling WH; Lu CY; et al. Which preventive measures might protect health care workers from SARS?. BMC Public Health. 2009; 9: 81 • Crossref • PubMed • Scopus (28) • Google Scholar ^| [115]47.03. Ki HK; Han SK; Son JS; Park SO. Risk of transmission via medical employees and importance of routine infection-prevention policy in a nosocomial outbreak of Middle East respiratory syndrome … Continue reading ^| [116]49.03. Kim CJ; Choi WS; Jung Y; et al. Surveillance of the Middle East respiratory syndrome (MERS) coronavirus (CoV) infection in healthcare workers after contact with confirmed MERS patients: … Continue reading ^| [117]51.03. Liu W; Tang F; Fang LQ. et al. Risk factors for SARS infection among hospital healthcare workers in Beijing: a case control study. Trop Med Int Health. 2009; 14: 52-59  • Crossref  • … Continue reading ^| [118]54.03. Ma HJ; Wang HW; Fang LQ. et al. A case-control study on the risk factors of severe acute respiratory syndromes among health care workers. Zhonghua Liu Xing Bing Xue Za Zhi. 2004; 25 (in … Continue reading ^| [119]58.03. Park BJ; Peck AJ; Kuehnert MJ. et al. Lack of SARS transmission among healthcare workers, United States. Emerg Infect Dis. 2004; 10: 244-248 • Crossref • PubMed • Google Scholar ^| [120]60.03. Peck AJ; Newbern EC; Feikin DR; et al. Lack of SARS transmission and U.S. SARS case-patient. Emerg Infect Dis. 2004; 10: 217-224 • Crossref  • PubMed • Scopus (11) • Google Scholar ^| [121]61.03. Pei LY; Gao ZC; Yang Z. et al. Investigation of the influencing factors on severe acute respiratory syndrome among health care workers. Beijing Da Xue Xue Bao Yi Xue Ban. 2006; 38: 271-275 • … Continue reading ^| [122]65.03. Ryu B; Cho SI; Oh MD. et al. Seroprevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) in public health workers responding to a MERS outbreak in Seoul, Republic of Korea, in … Continue reading ^| [123]75.03. Yin WW; Gao LD; Lin WS; et al. Effectiveness of personal protective measures in prevention of nosocomial transmission of severe acute respiratory syndrome. Zhonghua Liu Xing Bing Xue Za Zhi. … Continue reading addressed the association of eye protection with virus transmission.

Table 1 Characteristics of included comparative studies

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Table 1 Characteristics thelancet

Across studies, mean age was 30–60 years. SARS=severe acute respiratory syndrome. MERS=Middle East respiratory syndrome.

* The Newcastle-Ottawa Scale was used for the risk of bias assessment, with more stars equalling lower risk.
Some direct evidence was available for COVID-19 (64 studies, of which seven were comparative in design),^[124]36.02. Bai Y; Wang X; Huang Q; et al. SARS-CoV-2 infection in health care workers: a retrospective analysis and a model study. medRxiv. 2020; (published online April 1.) (preprint). DOI: … Continue reading ^| [125]37.04. Burke RM; Balter S; Barnes E; et al. Enhanced contact investigations for nine early travel-related cases of SARS-CoV-2 in the United States. medRxiv. 2020; (published online May 3.) … Continue reading ^| [126]40.02. Cheng H-Y; Jian S-W; Liu D-P; Ng T-C; Huang W-T; Lin H-H. High transmissibility of COVID-19 near symptom onset. medRxiv. 2020; (published online March 19.) (preprint). DOI: … Continue reading ^| [127]41.03. Wang X; Pan Z; Cheng Z; Association between 2019-nCoV transmission and N95 respirator use. J Hosp Infect. 2020; 105: 104-105 • Summary • Full Text • Full Text PDF  • PubMed • Scopus … Continue reading ^| [128]44.03. Heinzerling A; Stuckey MJ; Scheuer T. et al. Transmission of COVID-19 to health care personnel during exposures to a hospitalized patient: Solano County, California, February 2020. MMWR Morb … Continue reading ^| [129]52.03. Liu ZQ; Ye Y; Zhang H; Guohong X; Yang J; Wang JL. Analysis of the spatio-temporal characteristics and transmission path of COVID-19 cluster cases in Zhuhai. Trop Geogr. 2020; (published … Continue reading ^| [130]70.03. Wang Q; Huang X; Bai Y; et al. Epidemiological characteristics of COVID-19 in medical staff members of neurosurgery departments in Hubei province: a multicentre descriptive study. medRxiv. … Continue reading but most studies reported on SARS (n=55) or MERS (n=25; appendix pp 6–12). Of the 44 comparative studies, 40 included WHO-defined confirmed cases, one included both confirmed and probable cases, and the remaining three studies included probable cases. There was no effect-modification by case-definition (distance p_interaction=0·41; mask p_interaction=0·46; all cases for eye protection were confirmed). Most studies reported on bundled interventions, including different components of PPE and distancing, which was usually addressed by statistical adjustment. The included studies all occurred during recurrent or novel outbreak settings of COVID-19, SARS, or MERS.

Risk of bias was generally low-to-moderate after considering the observational designs (table 1), but both within studies and across studies the overall findings were similar between adjusted and unadjusted estimates. We did not detect strong evidence of publication bias in the body of evidence for any intervention (appendix pp 15–18). As we did not use case series data to inform estimates of effect of each intervention, we did not systematically rate risk of bias of these data. Therefore, we report further only those studies with comparative data.

Across 29 unadjusted and nine adjusted studies, ^[131]35.02. Arwady MA Alraddadi B, Basler C, et al. Middle East respiratory syndrome coronavirus transmission in extended family, Saudi Arabia, 2014. Emerg Infect Dis. 2016; 22: 1395-1402 • Crossref • … Continue reading ^| [132]36.03. Bai Y; Wang X; Huang Q; et al. SARS-CoV-2 infection in health care workers: a retrospective analysis and a model study. medRxiv. 2020; (published online April 1.) (preprint). DOI: … Continue reading ^| [133]37.05. Burke RM; Balter S; Barnes E; et al. Enhanced contact investigations for nine early travel-related cases of SARS-CoV-2 in the United States. medRxiv. 2020; (published online May 3.) … Continue reading ^| [134]39.03. Chen WQ; Ling WH; Lu CY; et al. Which preventive measures might protect health care workers from SARS?. BMC Public Health. 2009; 9: 81 • Crossref • PubMed • Scopus (28) • Google Scholar ^| [135]40.03. Cheng H-Y; Jian S-W; Liu D-P; Ng T-C; Huang W-T; Lin H-H. High transmissibility of COVID-19 near symptom onset. medRxiv. 2020; (published online March 19.) (preprint). DOI: … Continue reading ^| [136]43.03. Hall AJ; Tokars JI; Badreddine SA; et al. Health care worker contact with MERS patient, Saudi Arabia. Emerg Infect Dis. 2014; 20: 2148-2151 • Crossref • PubMed • Scopus (21) • Google … Continue reading ^| [137]44.04. Heinzerling A; Stuckey MJ; Scheuer T. et al. Transmission of COVID-19 to health care personnel during exposures to a hospitalized patient: Solano County, California, February 2020. MMWR Morb … Continue reading ^| [138]46.02. Van Kerkhove MD; Alaswad S; Assiri A. et al. Transmissibility of MERS-CoV infection in closed setting, Riyadh, Saudi Arabia, 2015. Emerg Infect Dis J. 2019; 25: 1802-1809 • Crossref • … Continue reading ^| [139]47.04. Ki HK; Han SK; Son JS; Park SO. Risk of transmission via medical employees and importance of routine infection-prevention policy in a nosocomial outbreak of Middle East respiratory syndrome … Continue reading ^| [140]50.02. Lau JTF; Lau M; Kim JH; Tsui HY; Tsang T; Wong TW. Probable secondary infections in households of SARS patients in Hong Kong. Emerg Infect Dis. 2004; 10: 235-243  • Crossref • PubMed • … Continue reading ^| [141]51.04. Liu W; Tang F; Fang LQ. et al. Risk factors for SARS infection among hospital healthcare workers in Beijing: a case control study. Trop Med Int Health. 2009; 14: 52-59  • Crossref  • … Continue reading ^| [142]52.04. Liu ZQ; Ye Y; Zhang H; Guohong X; Yang J; Wang JL. Analysis of the spatio-temporal characteristics and transmission path of COVID-19 cluster cases in Zhuhai. Trop Geogr. 2020; (published … Continue reading ^| [143]53.03. Loeb M; McGeer A; Henry B; et al. SARS among critical care nurses, Toronto. Emerg Infect Dis. 2004; 10: 251-255 • Crossref • PubMed • Scopus (165) • Google Scholar ^| [144]54.04. Ma HJ; Wang HW; Fang LQ. et al. A case-control study on the risk factors of severe acute respiratory syndromes among health care workers. Zhonghua Liu Xing Bing Xue Za Zhi. 2004; 25 (in … Continue reading ^| [145]56.03. Nishiyama A; Wakasugi N; Kirikae T. et al. Risk factors for SARS infection within hospitals in Hanoi, Vietnam. Jpn J Infect Dis. 2008; 61: 388-390  • PubMed • Google Scholar ^{| [146]}57.02. Olsen SJ; Chang HL; Cheung TY. et al. Transmission of the severe acute respiratory syndrome on aircraft. N Engl J Med. 2003; 349: 2416-2422 • Crossref  • PubMed • Scopus (301) • … Continue reading ^| [147]59.03. Park JY; Kim BJ; Chung KH; Hwang YI. Factors associated with transmission of Middle East respiratory syndrome among Korean healthcare workers: infection control via extended healthcare contact … Continue reading ^| [148]60.04. Peck AJ; Newbern EC; Feikin DR; et al. Lack of SARS transmission and U.S. SARS case-patient. Emerg Infect Dis. 2004; 10: 217-224 • Crossref  • PubMed • Scopus (11) • Google Scholar ^| [149]61.04. Pei LY; Gao ZC; Yang Z. et al. Investigation of the influencing factors on severe acute respiratory syndrome among health care workers. Beijing Da Xue Xue Bao Yi Xue Ban. 2006; 38: 271-275 • … Continue reading ^| [150]62.02. Rea E; Laflèche J; Stalker S. et al. Duration and distance of exposure are important predictors of transmission among community contacts of Ontario SARS cases. Epidemiol Infect. 2007; 135: … Continue reading ^| [151]63.02. Reuss A; Litterst A; Drosten C. et al. Contact investigation for imported case of Middle East respiratory syndrome, Germany. Emerg Infect Dis. 2014; 20: 620-625 • Crossref • PubMed • … Continue reading ^| [152]64.03. Reynolds MG; Anh BH; Thu VH. et al. Factors associated with nosocomial SARS-CoV transmission among healthcare workers in Hanoi, Vietnam, 2003. BMC Public Health. 2006; 6: 207 • Crossref • … Continue reading ^| [153]65.04. Ryu B; Cho SI; Oh MD. et al. Seroprevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) in public health workers responding to a MERS outbreak in Seoul, Republic of Korea, in … Continue reading ^| [154]66.03. Scales DC; Green K; Chan AK. et al. Illness in intensive care staff after brief exposure to severe acute respiratory syndrome. Emerg Infect Dis. 2003; 9: 1205-1210 • Crossref • PubMed • … Continue reading ^| [155]68.03. Teleman MD; Boudville IC; Heng BH; Zhu D; Leo YS. Factors associated with transmission of severe acute respiratory syndrome among health-care workers in Singapore. Epidemiol Infect. 2004; 132: … Continue reading ^| [156]69.03. Tuan PA; Horby P; Dinh PN. et al. SARS transmission in Vietnam outside of the health-care setting. Epidemiol Infect. 2007; 135: 392-401 • Crossref • PubMed • Scopus (4) • Google … Continue reading ^| [157]71.02. Wiboonchutikul S; Manosuthi W; Likanonsakul S; et al. Lack of transmission among healthcare workers in contact with a case of Middle East respiratory syndrome coronavirus infection in … Continue reading ^| [158]73.02. Wong TW; Lee CK; Tam W; et al. Cluster of SARS among medical students exposed to single patient, Hong Kong. Emerg Infect Dis. 2004; 10: 269-276 • Crossref  • PubMed • Scopus (145) • … Continue reading ^| [159]76.02. Yu ITS; Wong TW; Chiu YL; Lee N; Li Y. Temporal-spatial analysis of severe acute respiratory syndrome among hospital inpatients. Clin Infect Dis. 2005; 40: 1237-1243 • Crossref • PubMed … Continue reading a strong association was found of proximity of the exposed individual with the risk of infection (unadjusted n=10 736, RR 0·30, 95% CI 0·20 to 0·44; adjusted n=7782, aOR 0·18, 95% CI 0·09 to 0·38; absolute risk [AR] 12·8% with shorter distance vs 2·6% with further distance, risk difference [RD] −10·2%, 95% CI −11·5 to −7·5; moderate certainty; figure 2; table 2; appendix p 16).

Although there were six studies on COVID-19, the association was seen irrespective of causative virus (p_interaction=0·49), health-care setting versus non-health-care setting (p_interaction=0·14), and by type of face mask (p_interaction=0·95; appendix pp 17, 19).

However, different studies used different distances for the intervention. By meta-regression, the strength of association was larger with increasing distance (2·02 change in RR per m, 95% CI 1·08 to 3·76; p_interaction=0·041; moderate credibility subgroup effect; figure 3A; table 2). AR values with increasing distance given different degrees of baseline risk are shown in figure 3B, with potential values at 3 m also shown.

Figure 2 Forest plot showing the association of COVID-19, SARS, or MERS exposure proximity with infection

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Table 2 GRADE summary of findings

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Table 2 GRADE- thelancet

Table based on GRADE approach. ^26–29 Population comprised people possibly exposed to individuals infected with SARS-CoV-2, SARS-CoV, or MERS-CoV. Setting was any health-care or non-health-care setting. Outcomes were infection (laboratory-confirmed or probable) and contextual factors.

Risk (95% CI) in intervention group is based on assumed risk in comparison group and relative effect (95% CI) of the intervention. All studies were non-randomised and evaluated using the Newcastle-Ottawa Scale; some studies had a higher risk of bias than did others but no important difference was noted in sensitivity analyses excluding studies at higher risk of bias; we did not further rate down for risk of bias.

Although there was a high I ² value (which can be exaggerated in non-randomised studies) ²¹ and no overlapping CIs, point estimates generally exceeded the thresholds for large effects and we did not rate down for inconsistency.

We did not rate down for indirectness for the association between distance and infection because SARS-CoV-2, SARS-CoV, and MERS-CoV all belong to the same family and have each caused epidemics with sufficient similarity; there was also no convincing statistical evidence of effect-modification across viruses; some studies also used bundled interventions but the studies include only those that provide adjusted estimates. aOR=adjusted odds ratio. RR=relative risk. SARS-CoV-2=severe acute respiratory syndrome coronavirus 2. SARS-CoV=severe acute respiratory syndrome coronavirus. MERS-CoV=Middle East respiratory syndrome coronavirus.

* GRADE category of evidence; high certainty (we are very confident that the true effect lies close to that of the estimate of the effect); moderate certainty (we are moderately confident in the effect estimate; the true effect is probably close to the estimate, but it is possibly substantially different); low certainty (our confidence in the effect estimate is limited; the true effect could be substantially different from the estimate of the effect); very low certainty (we have very little confidence in the effect estimate; the true effect is likely to be substantially different from the estimate of effect).

† The effect is very large considering the thresholds set by GRADE, particularly at plausible levels of baseline risk, which also mitigated concerns about risk of bias; data also suggest a dose–response gradient, with associations increasing from smaller distances to 2 m and beyond, by meta-regression; we did not rate up for this domain alone but it further supports the decision to rate up in combination with the large effects.

‡ The effect was very large, and the certainty of evidence could be rated up, but we made a conservative decision not to because of some inconsistency and risk of bias; hence, although the effect is qualitatively highly certain, the precise quantitative effect is low certainty.

§ In a subgroup analysis comparing N95 respirators with surgical or similar masks (eg, 12–16-layer cotton), the association was more pronounced in the N95 group (aOR 0·04, 95% CI 0·004–0·30) compared with other masks (0·33, 0·17–0·61; p _interaction=0·090); there was also support for effect-modification by formal analysis of subgroup credibility.

¶ Two studies ^54,75 provided adjusted estimates with n=295 in the eye protection group and n=406 in the group not wearing eye protection; results were similar to the unadjusted estimate (aOR 0·22, 95% CI 0·12–0·39).

‖ The effect is large considering the thresholds set by GRADE assuming that ORs translate into similar magnitudes of RR estimates; this mitigates concerns about risk of bias, but we conservatively decided not to rate up for large or very large effects.

Figure 3 Change in relative risk with increasing distance and absolute risk with increasing distance

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Across 29 unadjusted studies and ten adjusted studies,^[160]34.02. Alraddadi BM Al-Salmi HS Jacobs-Slifka K et al. Risk factors for Middle East respiratory syndrome coronavirus infection among healthcare personnel. Emerg Infect Dis. 2016; 22: 1915-1920  • … Continue reading ^{| [161]}37.06. Burke RM; Balter S; Barnes E; et al. Enhanced contact investigations for nine early travel-related cases of SARS-CoV-2 in the United States. medRxiv. 2020; (published online May 3.) … Continue reading | ^[162]41.04. Wang X; Pan Z; Cheng Z; Association between 2019-nCoV transmission and N95 respirator use. J Hosp Infect. 2020; 105: 104-105 • Summary • Full Text • Full Text PDF  • PubMed • Scopus … Continue reading | ^[163]42.03. Ha LD; Bloom SA; Hien NQ; et al. Lack of SARS transmission among public hospital workers, Vietnam. Emerg Infect Dis. 2004; 10: 265-268 • Summary • Full Text • Full Text PDF • Crossref … Continue reading | ^[164]43.04. Hall AJ; Tokars JI; Badreddine SA; et al. 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Zhonghua Liu Xing Bing Xue Za Zhi. … Continue reading the use of both N95 or similar respirators or face masks (eg, disposable surgical masks or similar reusable 12–16-layer cotton masks) by those exposed to infected individuals was associated with a large reduction in risk of infection (unadjusted n=10 170, RR 0·34, 95% CI 0·26 to 0·45; adjusted studies n=2647, aOR 0·15, 95% CI 0·07 to 0·34; AR 3·1% with face mask vs 17·4% with no face mask, RD −14·3%, 95% CI −15·9 to −10·7; low certainty; figure 4; table 2; appendix pp 16, 18) with stronger associations in health-care settings (RR 0·30, 95% CI 0·22 to 0·41) compared with non-health-care settings (RR 0·56, 95% CI 0·40 to 0·79; p_interaction=0·049; low-to-moderate credibility for subgroup effect; figure 4; appendix p 19).

The use of face masks was protective for both health-care workers and people in the community exposed to infection, with both the frequentist and Bayesian analyses lending support to face mask use irrespective of setting. Our unadjusted analyses might, at first impression, suggest use of face masks in the community setting to be less effective than in the health-care setting, but after accounting for differential N95 respirator use between health-care and non-health-care settings, we did not detect any striking differences in effectiveness of face mask use between settings. The credibility of effect-modification across settings was, therefore, low. Wearing face masks was also acceptable and feasible. Policy makers at all levels should, therefore, strive to address equity implications for groups with currently limited access to face masks and eye protection. One concern is that face mask use en masse could divert supplies from people at highest risk for infection.^[225]10.02. Feng S Shen C Xia N Song W Fan M Cowling BJ Rational use of face masks in the COVID-19 pandemic. Lancet Respir Med. 2020; 8: 434-436 • Summary • Full Text • Full Text PDF  • PubMed … Continue reading

Health-care workers are increasingly being asked to ration and reuse PPE,^[226]82.01. Rimmer A; COVID-19: experts question guidance to reuse PPE. BMJ.2020; 369m1577 • Crossref • PubMed • Scopus (2) • Google Scholar ^{| [227]}83.01. Mackenzie D; Reuse of N95 masks. Engineering. 2020; (published online April 13.) DOI:10.1016/j.eng.2020.04.003 • Crossref  • Google Scholar leading to calls for government-directed repurposing of manufacturing capacity to overcome mask shortages^[228]84.01. Greenhalgh T; Schmid MB; Czypionka T; Bassler D; Gruer L. Face masks for the public during the covid-19 crisis. BMJ. 2020; 369m1435 • Crossref • PubMed • Scopus (46) • Google Scholar and finding solutions for mask use by the general public.^[229]84.02. Greenhalgh T; Schmid MB; Czypionka T; Bassler D; Gruer L. Face masks for the public during the covid-19 crisis. BMJ. 2020; 369m1435 • Crossref • PubMed • Scopus (46) • Google Scholar

In this respect, some of the masks studied in our review were reusable 12–16-layer cotton or gauze masks.^[230]51.08. Liu W; Tang F; Fang LQ. et al. Risk factors for SARS infection among hospital healthcare workers in Beijing: a case control study. Trop Med Int Health. 2009; 14: 52-59  • Crossref  • … Continue reading ^| [231]54.08. Ma HJ; Wang HW; Fang LQ. et al. A case-control study on the risk factors of severe acute respiratory syndromes among health care workers. Zhonghua Liu Xing Bing Xue Za Zhi. 2004; 25 (in … Continue reading ^| [232]61.08. Pei LY; Gao ZC; Yang Z. et al. Investigation of the influencing factors on severe acute respiratory syndrome among health care workers. Beijing Da Xue Xue Bao Yi Xue Ban. 2006; 38: 271-275 • … Continue reading ^| [233]75.07. Yin WW; Gao LD; Lin WS; et al. Effectiveness of personal protective measures in prevention of nosocomial transmission of severe acute respiratory syndrome. Zhonghua Liu Xing Bing Xue Za Zhi. … Continue reading

At the moment, although there is consensus that SARS-CoV-2 mainly spreads through large droplets and contact, debate continues about the role of aerosol,^[234]02.02. Guo ZD Wang ZY Zhang SF et al. Aerosol and surface distribution of severe acute respiratory syndrome coronavirus 2 in hospital wards, Wuhan, China, 2020. Emerg Infect Dis. 2020; (published … Continue reading ^{| [235]}03.02. Chia PY Coleman KK Tan YK et al. Detection of air and surface contamination by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in hospital rooms of infected patients. medRxiv. … Continue reading ^| [236]04.02. Santarpia JL Rivera DN Herrera V et al. Transmission potential of SARS-CoV-2 in viral shedding observed at the University of Nebraska Medical Center. medRxiv. 2020; (published online March … Continue reading ^| [237]05.02. Cheng V Wong S-C Chen J et al. Escalating infection control response to the rapidly evolving epidemiology of the coronavirus disease 2019 (COVID-19) due to SARS-CoV-2 in Hong Kong. Infect … Continue reading ^| [238]06.02. Wong SCY Kwong RT-S Wu TC et al. Risk of nosocomial transmission of coronavirus disease 2019: an experience in a general ward setting in Hong Kong. J Hosp Infect. 2020; 105: 119-127 • … Continue reading ^| [239]07.02. Faridi S Niazi S Sadeghi K et al. A field indoor air measurement of SARS-CoV-2 in the patient rooms of the largest hospital in Iran. Sci Total Environ. 2020; 725138401 • Crossref • PubMed … Continue reading ^| [240]08.02. Ong SWX Tan YK Chia PY et al. Air, surface environmental, and personal protective equipment contamination by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from a symptomatic … Continue reading ^| [241]85.01. Bahl P; Doolan C; de Silva C; Chughtai AA; Bourouiba L; MacIntyre CR; Airborne or droplet precautions for health workers treating coronavirus disease 2019?. J Infect Dis. 2020; (published … Continue reading ^{| [242]}86.01. Schünemann HJ; Khabsa J; Solo K; et al. Ventilation techniques and risk for transmission of coronavirus disease, including COVID-19: a living systematic review of multiple streams of … Continue reading but our meta-analysis provides evidence (albeit of low certainty) that respirators might have a stronger protective effect than surgical masks. Biological plausibility would be supported by data for aerosolised SARS-CoV-2^[243]05.03. Cheng V Wong S-C Chen J et al. Escalating infection control response to the rapidly evolving epidemiology of the coronavirus disease 2019 (COVID-19) due to SARS-CoV-2 in Hong Kong. Infect … Continue reading | ^[244]06.03. Wong SCY Kwong RT-S Wu TC et al. Risk of nosocomial transmission of coronavirus disease 2019: an experience in a general ward setting in Hong Kong. J Hosp Infect. 2020; 105: 119-127 • … Continue reading | ^[245]07.03. Faridi S Niazi S Sadeghi K et al. A field indoor air measurement of SARS-CoV-2 in the patient rooms of the largest hospital in Iran. Sci Total Environ. 2020; 725138401 • Crossref • PubMed … Continue reading | ^[246]08.03. Ong SWX Tan YK Chia PY et al. Air, surface environmental, and personal protective equipment contamination by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from a symptomatic … Continue reading | and preclinical data showing seasonal coronavirus RNA detection in fine aerosols during tidal breathing,^[247]87.01. Leung NHL; Chu DKW; Shiu EYC; et al. Respiratory virus shedding in exhaled breath and efficacy of face masks. Nat Med. 2020; 26: 676-680 • Crossref • PubMed • Scopus (131) • Google … Continue reading albeit, RNA detection does not necessarily imply replication and infection-competent virus. Nevertheless, our findings suggest it plausible that even in the absence of aerosolisation, respirators might be simply more effective than masks at preventing infection.

At present, there is no data to support viable virus in the air outside of aerosol generating procedures from available hospital studies. Other factors such as super-spreading events, the subtype of health-care setting (eg, emergency room, intensive care unit, medical wards, dialysis centre), if aerosolising procedures are done, and environmental factors such as ventilation, might all affect the degree of protection afforded by personal protection strategies, but we did not identify robust data to inform these aspects.

Strengths of our review include adherence to full systematic review methods, which included artificial intelligence-supported dual screening of titles and abstracts, full-text evaluation, assessment of risk of bias, and no limitation by language. We included patients infected with SARS-CoV-2, SARS-CoV, or MERS-CoV and searched relevant data up to May 3, 2020. We followed the GRADE approach^[248]16.02. Guyatt GH Oxman AD Vist GE et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008; 336: 924-926 • Crossref • PubMed • Google Scholar to rate the certainty of evidence. Finally, we identified and appraise a large body of published work from China, from which much evidence emerged before the pandemic spread to other global regions.

The primary limitation of our study is that all studies were non-randomised, not always fully adjusted, and might suffer from recall and measurement bias (eg, direct contact in some studies might not be measuring near distance).

However, unadjusted, adjusted, frequentist, and Bayesian meta-analyses all supported the main findings, and large or very large effects were recorded. Nevertheless, we are cautious not to be overly certain in the precise quantitative estimates of effects, although the qualitative effect and direction is probably of high certainty.

Many studies did not provide information on precise distances, and direct contact was equated to 0 m distance; none of the eligible studies quantitatively evaluated whether distances of more than 2 m were more effective, although our meta-regression provides potential predictions for estimates of risk.

Few studies assessed the effect of interventions in non-health-care settings, and they primarily evaluated mask use in households or contacts of cases, although beneficial associations were seen across settings.

Furthermore, most evidence was from studies that reported on SARS and MERS (n=6674 patients with COVID-19, of 25 697 total), but data from these previous epidemics provide the most direct information for COVID-19 currently.

We did not specifically assess the effect of duration of exposure on risk for transmission, although whether or not this variable was judged a risk factor considerably varied across studies, from any duration to a minimum of 1 h.

Because of inconsistent reporting, information is limited about whether aerosol-generating procedures were in place in studies using respirators, and whether masks worn by infected patients might alter the effectiveness of each intervention, although the stronger association with N95 or similar respirators over other masks persisted when adjusting for studies reporting aerosol-generating medical procedures.

These factors might account for some of the residual statistical heterogeneity seen for some outcomes, albeit I2 is commonly inflated in meta-analyses of observational data, ^[249]21.05. Guyatt GH Oxman AD Kunz R et al. GRADE guidelines, 7: rating the quality of evidence—inconsistency. J Clin Epidemiol. 2011; 64: 1294-1302 • Summary • Full Text • Full Text PDF • … Continue reading ^| [250]22.02 Iorio A Spencer FA Falavigna M et al. Use of GRADE for assessment of evidence about prognosis: rating confidence in estimates of event rates in broad categories of patients. BMJ. 2015; 350: … Continue reading and nevertheless the effects seen were large and probably clinically important in all adjusted studies.

Our comprehensive systematic review provides the best available information on three simple and common interventions to combat the immediate threat of COVID-19, while new evidence on pharmacological treatments, vaccines, and other personal protective strategies is being generated. Physical distancing of at least 1 m is strongly associated with protection, but distances of up to 2 m might be more effective.

Although direct evidence is limited, the optimum use of face masks, in particular N95 or similar respirators in health-care settings and 12–16-layer cotton or surgical masks in the community, could depend on contextual factors; action is needed at all levels to address the paucity of better evidence. Eye protection might provide additional benefits.

Globally collaborative and well conducted studies, including randomised trials, of different personal protective strategies are needed regardless of the challenges, but this systematic appraisal of currently best available evidence could be considered to inform interim guidance.

Contributors

DKC, EAA, SD, KS, SY, and HJS designed the study. SY, SD, KS, and HJS coordinated the study. SY and LH designed and ran the literature search. All authors acquired data, screened records, extracted data, and assessed risk of bias. DKC did statistical analyses. DKC and HJS wrote the report. All authors provided critical conceptual input, analysed and interpreted data, and critically revised the report.

COVID-19 Systematic Urgent Review Group Effort (SURGE) study authors

Argentina—German Hospital of Buenos Aires (Ariel Izcovich); Canada—Cochrane Consumer Executive (Maureen Smith); McMaster University (Mark Loeb, Anisa Hajizadeh, Carlos A Cuello-Garcia, Gian Paolo Morgano, Leila Harrison, Tejan Baldeh, Karla Solo, Tamara Lotfi, Antonio Bognanni, Rosa Stalteri, Thomas Piggott, Yuan Zhang, Stephanie Duda, Derek K Chu, Holger J Schünemann); Southlake Regional Health Centre (Jeffrey Chan); University of British Columbia (David James Harris); Chile—Pontificia Universidad Católica de Chile (Ignacio Neumann); China—Beijing University of Chinese Medicine, Dongzhimen Hospital (Guang Chen); Guangzhou University of Chinese Medicine, The Fourth Clinical Medical College (Chen Chen); China Academy of Chinese Medical Sciences (Hong Zhao); Germany—Finn Schünemann; Italy—Azienda USL–IRCCS di Reggio Emilia (Paolo Giorgi Rossi); Universita Vita-Salute San Raffaele, Milan, Italy (Giovanna Elsa Ute Muti Schünemann); Lebanon—American University of Beirut (Layal Hneiny, Amena El-Harakeh, Fatimah Chamseddine, Joanne Khabsa, Nesrine Rizk, Rayane El-Khoury, Zahra Saad, Sally Yaacoub, Elie A Akl); Rafik Hariri University Hospital (Pierre AbiHanna); Poland—Evidence Prime, Krakow (Anna Bak, Ewa Borowiack); UK—The London School of Hygiene & Tropical Medicine (Marge Reinap); University of Hull (Assem Khamis).

Declaration of interests

ML is an investigator of an ongoing clinical trial on medical masks versus N95 respirators for COVID-19 (NCT04296643). All other authors declare no competing interests.

Acknowledgements

This systematic review was commissioned and in part paid for by WHO. The authors alone are responsible for the views expressed in this article and they do not necessarily represent the decisions, policy, or views of WHO. We thank Susan L Norris, April Baller, and Benedetta Allegranzi (WHO) for input in the protocol or the final article; Xuan Yu (Evidence Based Medicine Center of Lanzhou University, China), Eliza Poon, and Yuqing (Madison) Zhang for assistance with Chinese literature support; Neera Bhatnagar and Aida Farha (information specialists) for peer-reviewing the search strategy; Artur Nowak (Evidence Prime, Hamilton, ON, Canada) for help with searching and screening using artificial intelligence; and Christine Keng for additional support. DKC is a CAAIF-CSACI-AllerGen Emerging Clinician-Scientist Research Fellow, supported by the Canadian Allergy, Asthma and Immunology Foundation (CAAIF), the Canadian Society of Allergy and Clinical Immunology (CSACI), and AllerGen NCE (the Allergy, Genes and Environment Network).

Editorial note: the Lancet Group takes a neutral position with respect to territorial claims in published maps and institutional affiliations.

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DAILY MAIL HEADLINES: The land with no face masks: Holland’s top scientists say there’s no solid evidence coverings work and warn they could even damage the fight against COVID-19  https://www.dailymail.co.uk/news/article-8583925/The-land-no-face-masks-Hollands-scientists-say-theres-no-solid-evidence-coverings-work.html By Ian Birrell in Amsterdam for the Mail On Sunday Published: 07:05 AEST, 2 August 2020 | UPDATED: 21:07 AEST, 4 August 2020

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